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他山之石|国外对栗蘑(灰树花)的抗糖尿病机制的论述

2017-4-11 14:38:27      点击:

灰树花多糖对血糖的调节作用(二)

(国外文献摘要)

灰树花的抗糖尿病机制

食用菌生物学和食用菌产品

Roye(ed)著  宾夕法尼亚州立大学  1996,ISBN 1-883956-01-3

在非胰岛素依赖型(Ⅰ型)糖尿病KK-Ay小鼠体内进行了葡萄糖耐受试验。饲喂灰树花15分钟和30分钟后,试验组小鼠的血糖上升水平仅仅分别是对照组的0.64倍和0.76倍,灰树花明显抑制血糖的上升。应用肝脏灌注法检查了肝细胞胰岛素受体能力,从灰树花饲喂组中观察到对血糖的下降作用,同时,在对照组中观察到对血糖的耐受状态。其次,检查了消化道葡萄糖的吸收活性和小肠粘膜蔗糖酶的活性,当饲喂灰树花粉或X-fraction时,既没有观察到小肠中葡萄糖的抑制,也没有蔗糖酶活性的抑制。以上结果显示,灰树花的抗糖尿病活性,与消化道葡萄糖的吸收抑制没有关系,但与葡萄糖吸收后的代谢过程相关。

Anti-Diabetic Mechanism of Maitake (Grifola frondosa),

Mushroom Biology and Mushroom Products

Royse (ed.) 1996 Penn State Univ. ISBN 1-883956-01-3


(Abstract)

Glucose tolerance tests were conducted on KK-Ay mice,model animals of NIDDM(non-insulin dependent diabetes mellitus). The elevated blood glucose levels after 15 minutes and 30minutes of Maitake-fed group were 0.64 times and 0.76 times those of the control group respectively, indicating inhibition of a significant blood glucose increase. Insulin receptor capability of liver cells then was examined using the liver perfusion method. Downward regulation was observed among the Maitake-fed group,while a state of tolerance was seen among the control group.Next,glucose absorption activity at the enteron and sucrase activity at the mucosa of the small intestine were examined.Neither inhibition of glucose at the small intestine nor inhibition of sucrase activation was observed when Maitake powder or X-fractioon was administered.These results suggested that Maitake’s anti-diabetic activity is not related to the inhibition of glucose absorption at the enteron,but with the process of metabolism of absorbed gulcose.