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国外文献摘要//灰树花多糖对血糖的调节作用

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灰树花多糖对血糖的调节作用

(国外文献摘要)

灰树花的抗糖尿病作用

生物药物通报,17卷,1994

担子菌真菌灰树花,已被肯定含有抗糖尿病活性的物质。灰树花粉1g/天的剂量饲喂病源性糖尿病小鼠(KK-Ay),可观察到血糖的降低。对照组中的小鼠血糖却增加。从灰树花中制备了醚醇溶物(ES)和水溶物两种组分,并检测了其降低血糖的活性。口服醚醇溶物或50%乙醇悬浮的水溶物(X)时,有降低血糖的活性,但其他水溶性多糖成分为表现此活性。这些结果提示,抗糖尿病活性不仅表现在由脂质成分构成的醇醚溶物中,而且表现在水溶性的糖蛋白中(其组成为糖:蛋白质=65:35)。

Literature on Regulating Blood Sugar

(a complete paper may be available upon request)


Anti-diabetic Activity Present in the Fruit Body of Grifola frondosa (Maitake) Biol.Pharm.Bull.17(8) P.1106-1110(1994),


(Abstract)

The fruit body of Grifola frondosa (maitake),Basidiomycetes was confirmed to contain substances with anti-diabetic activity.When 1g/d of powdered fruit body of maitake was given orally to a genetically diabetic mouse (KK-Ay),blood glucose reduction was observed,in contrast to the control group in which the blood glucose increased with feeding of maitake.Ether-ethanol-soluble (ES) and hot water-soluble (WS) fractions were prepared from the fruit body and their hypoglycemic activity was examined.Blood glucose-lowering activity was found when ES-fraction or WE-50% ethanol float (X) was administered orally.but other WS-fraction were inactive.These results suggest that the anti-diabet activity was present not only in the ES-fraction consisting of lipid but also in the X-fraction of peptidoglycan (sugar:protein=65:35).